Only the lipid-soluble forms, for example the base, propionate or stearate, are effective.
A topical 2% erythromycin gel has been shown to be as effective as 1% clindamycin phosphate in patients with mild to moderate acne. Clindamycin is as effective as oral minocycline 50mg twice a day, and oral tetracyline. Clindamycin was found to be as effective as 5% benzoyl peroxide gel in patients with papular or pustular acne in some persons. Erytromycin is commonly used for infantile acne and during pregnancy. Now a days resistance to erythromycin is the more common, and such organisms share a cross-resistance to clindamycin. Topical antibiotic resistance should be suspected in four circumstances:1if the patient fails to respond;2 if the patient relapses while on therapy;3 if the patient has had multiple courses of oral and topical antibiotics;4 if the patient has a history of poor compliance with therapy. In such cases alternative therapy may be necessary depending upon the circumstances. Among the side effects allrgic contact dermatitis is rare bur irritant dermatitis is quite common.
A topical 2% erythromycin gel has been shown to be as effective as 1% clindamycin phosphate in patients with mild to moderate acne. Clindamycin is as effective as oral minocycline 50mg twice a day, and oral tetracyline. Clindamycin was found to be as effective as 5% benzoyl peroxide gel in patients with papular or pustular acne in some persons. Erytromycin is commonly used for infantile acne and during pregnancy. Now a days resistance to erythromycin is the more common, and such organisms share a cross-resistance to clindamycin. Topical antibiotic resistance should be suspected in four circumstances:1if the patient fails to respond;2 if the patient relapses while on therapy;3 if the patient has had multiple courses of oral and topical antibiotics;4 if the patient has a history of poor compliance with therapy. In such cases alternative therapy may be necessary depending upon the circumstances. Among the side effects allrgic contact dermatitis is rare bur irritant dermatitis is quite common.
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