Severe acne vulgaris is associated with significantly more oxidative stress than mild or moderate forms of the disease, study findings suggest.
To deal with the harmful effects of reactive oxygen species, the skin is equipped with antioxidant defense mechanisms. Superoxide dismutase (SOD) constitutes an important fraction of the antioxidant capacity of living cells to prevent oxidative injury and maintain skin homeostasis.
Prior studies have proposed the role of oxidative stress in the etiopathogenesis of acne. To investigate further, Abdel Fattah and colleagues from Ain Shams University in Cairo, Egypt, conducted a case-control study to assess the role of oxidative stress in different grades of acne severity.
