Nicotinamide

The marked anti-inflammatory properties of topical nicotinamide, the amide derivative of vitamin B3 (niacin), have been used to treat acne vulgaris.Nicotinamide, (Vitamin B3) used topically in the form of a gel, has been shown in a 1995 study to be more effective than a topical antibiotic used for comparison, as well as having fewer side effects. Topical nicotinamide is available both on prescription and over-the-counter. The property of topical nicotinamide's benefit in treating acne seems to be its anti-inflammatory nature. It is also purported to result in increased synthesis of collagen, keratin, involucrin and flaggrin.It is often combined with topical antibiotics