Before the advent of the retinoids and antiandrogens, several other therapies were used, and may occasionally be tried in difficult cases of acne if the newer drugs are contraindicated, unobtainable or ineffective. Oral zinc, certain non-steroidal anti-inflammatory drugs, such as ibuprofen and benoxaprofen, have been shown to reduce inflamed lesions.Clofazimine (200mg three times a week) has been shown to improve acne fulminans, but should not be given as a first option. Dapsone (100-300mg/day for 6 months) has also been tried with varied success.
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